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Childhood cancer survivors (CCSs) have an increased risk of overweight and dyslipidaemia, but the distribution and the potential relationships between anticancer therapies and cardiovascular risk factors have been heterogeneously and not prospectively described.All consecutive CCSs with primary cancer diagnosed between 1973-2007 and subsequently referred to our outpatient clinic were enrolled. Hypercholesterolaemia (total cholesterol >200 and/or low density lipoprotein (LDL)>160 mg/dl) was the primary end point, hypertriglyceridaemia (triglycerides >200 mg/dl) and body mass index >30 kg/m(2) the secondary end points. Cox multivariate adjustments were performed to account for differences in cancer and treatments.A total of 340 patients were included (197 male, 143 female; mean age at last follow-up 24.1 ± 3.2). The most common diagnosis were haematological malignancies (n = 227) and brain tumours (n = 51). After a median follow-up of 16.1 years, hypercholesterolaemia was diagnosed in 67 CCSs (20

作者:Francesco, Felicetti;Fabrizio, D'Ascenzo;Claudio, Moretti;Andrea, Corrias;Pierluigi, Omedè;Walter Grosso, Marra;Emanuela, Arvat;Franca, Fagioli;Enrico, Brignardello;Fiorenzo, Gaita

来源:European journal of preventive cardiology 2015 年 22卷 6期

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作者:
Francesco, Felicetti;Fabrizio, D'Ascenzo;Claudio, Moretti;Andrea, Corrias;Pierluigi, Omedè;Walter Grosso, Marra;Emanuela, Arvat;Franca, Fagioli;Enrico, Brignardello;Fiorenzo, Gaita
来源:
European journal of preventive cardiology 2015 年 22卷 6期
标签:
Childhood cancer survivors cardiovascular risk dyslipidaemia late-effects long-term follow-up obesity
Childhood cancer survivors (CCSs) have an increased risk of overweight and dyslipidaemia, but the distribution and the potential relationships between anticancer therapies and cardiovascular risk factors have been heterogeneously and not prospectively described.All consecutive CCSs with primary cancer diagnosed between 1973-2007 and subsequently referred to our outpatient clinic were enrolled. Hypercholesterolaemia (total cholesterol >200 and/or low density lipoprotein (LDL)>160 mg/dl) was the primary end point, hypertriglyceridaemia (triglycerides >200 mg/dl) and body mass index >30 kg/m(2) the secondary end points. Cox multivariate adjustments were performed to account for differences in cancer and treatments.A total of 340 patients were included (197 male, 143 female; mean age at last follow-up 24.1 ± 3.2). The most common diagnosis were haematological malignancies (n = 227) and brain tumours (n = 51). After a median follow-up of 16.1 years, hypercholesterolaemia was diagnosed in 67 CCSs (20