Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales.-临床诊疗知识库

Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales.

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作者：

Judith M, Sonder；Lisanne J, Balk；Libertje V A E, Bosma；Chris H, Polman；Bernard M J, Uitdehaag

来源：

Multiple sclerosis (Houndmills, Basingstoke, England) 2014 年 20卷 12期

标签：

Multiple sclerosis anxiety and depression caregiver burden outcome measurement patient-reported outcome proxy

Patient-reported outcome scales (PROs) are useful in monitoring changes in multiple sclerosis (MS) over time. Although these scales are reliable and valid measures in longitudinal studies in MS patients, it is unknown what the impact is when obtaining longitudinal data from proxies.The objective of this paper is to compare longitudinal changes in patient and proxy responses on PROs assessing physical impact of MS and walking ability.In a prospective observational study, data on the Multiple Sclerosis Impact Scale (MSIS-29 physical) and Multiple Sclerosis Walking Scale (MSWS-12) were obtained from 137 patient-proxy couples at baseline and at two-year follow-up. Demographic and disease-related variables explaining agreement or disagreement between patients and proxies were investigated using linear regression analyses.Full agreement was found in 56

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