Identification of novel IP receptor agonists using historical ligand biased chemical arrays.-临床诊疗知识库

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By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.

作者：Stephen C, McKeown；Steven J, Charlton；Brian, Cox；Helen, Fitch；Christopher D, Howson；Catherine, Leblanc；Arndt, Meyer；Elizabeth M, Rosethorne；Emily, Stanley

来源：Bioorganic & medicinal chemistry letters 2014 年 24卷 10期

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Identification of novel IP receptor agonists using historical ligand biased chemical arrays.

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作者：

Stephen C, McKeown；Steven J, Charlton；Brian, Cox；Helen, Fitch；Christopher D, Howson；Catherine, Leblanc；Arndt, Meyer；Elizabeth M, Rosethorne；Emily, Stanley

来源：

Bioorganic & medicinal chemistry letters 2014 年 24卷 10期

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IP agonist PGI(2) agonist Prostanoid Pulmonary arterial hypertension

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