Comorbidities are common in heart failure (HF), and the number of comorbidities has been associated with poor outcomes in HF patients. However, little is known about the effect of multiple comorbidities on cardiac mechanics, which could impact the pathogenesis of HF. We sought to determine the relationship between comorbidity burden and adverse cardiac mechanics.We performed speckle-tracking analysis on echocardiograms from the HyperGEN study (n=2150). Global longitudinal, circumferential, and radial strain, and early diastolic (e') tissue velocities were measured. We evaluated the association between comorbidity number and cardiac mechanics using linear mixed effects models to account for relatedness among subjects. The mean age was 51 ± 14 years, 58

作者：Senthil, Selvaraj；Frank G, Aguilar；Eva E, Martinez；Lauren, Beussink；Kwang-Youn A, Kim；Jie, Peng；Laura, Rasmussen-Torvik；Jin, Sha；Marguerite R, Irvin；C Charles, Gu；Cora E, Lewis；Steven C, Hunt；Donna K, Arnett；Sanjiv J, Shah

来源：Journal of the American Heart Association 2014 年 3卷 3期