Increased height is a known independent risk factor for atrial fibrillation (AF). However, whether genetic determinants of height influence risk is uncertain. In this candidate gene study, we examined the association of 209 height-associated single-nucleotide polymorphisms (SNPs) with incident AF in 3,309 persons of European descent from the Cardiovascular Health Study, a prospective cohort study of older adults (aged ≥ 65 years) enrolled in 1989-1990. After a median follow-up period of 13.2 years, 879 participants developed incident AF. The height-associated SNPs together explained approximately 10

作者：Michael A, Rosenberg；Robert C, Kaplan；David S, Siscovick；Bruce M, Psaty；Susan R, Heckbert；Christopher, Newton-Cheh；Kenneth J, Mukamal

来源：American journal of epidemiology 2014 年 180卷 2期