Thrombotic thrombocytopenic purpura (TTP) requires immediate treatment with plasma exchange (PE) to prevent disease mortality and/or morbidity. Frequently, PE is initiated before blood sample is collected to confirm ADAMTS13 deficiency. However, the effect of PE treatments on the evaluation of ADAMTS13 is uncertain. Moreover, the pertinence of ADAMTS13 activity during PE therapy to prediction of treatment outcomes is unclear. Thus, clarification of the diagnostic and prognostic values of ADAMTS13 activity obtained during PE treatment is an unmet clinical need.A total of 212 sequential samples were obtained during the course of daily PE treatment from 19 patients with acquired TTP. ADAMTS13 activity levels were determined in these longitudinal samples for analysis.After the initial three daily PE procedures, the sensitivities of ADAMTS13 activity in diagnosis of TTP (<10

作者：Nan, Wu；Jia, Liu；Shangbin, Yang；Eric T, Kellett；Spero R, Cataland；Hong, Li；Haifeng M, Wu

来源：Transfusion 2015 年 55卷 1期