Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The probiotic bacterium Escherichia coli Nissle 1917 (EcN) has been used to maintain and induce clinical remission in UC. Our aim was to test the effect of Ciprofloxacin and/or orally administered EcN as add-on to conventional therapies in patients with active UC.Our single center double-blinded randomized placebo controlled study included patients with a Colitis Activity Index (CAI) score of at least 6. Patients were randomized to Ciprofloxacin or placebo for 1week followed by EcN or placebo for 7weeks. All 4 treatments were given as add-on treatments.One hundred subjects with active UC were recruited. In the per-protocol analysis we, surprisingly, found that in the group receiving placebo/EcN fewer patients, 54

作者：Andreas Munk, Petersen；Hengameh, Mirsepasi；Sofie Ingdam, Halkj?r；Esben Munk, Mortensen；Inge, Nordgaard-Lassen；Karen Angeliki, Krogfelt

来源：Journal of Crohn's & colitis 2014 年 8卷 11期