Heart failure with reduced ejection fraction and obstructive sleep apnea (OSA), 2 states of increased metabolic demand and sympathetic nervous system activation, often coexist. Continuous positive airway pressure (CPAP), which alleviates OSA, can improve ventricular function. It is unknown whether this is due to altered oxidative metabolism or presynaptic sympathetic nerve function. We hypothesized that short-term (6-8 weeks) CPAP in patients with OSA and heart failure with reduced ejection fraction would improve myocardial sympathetic nerve function and energetics.Forty-five patients with OSA and heart failure with reduced ejection fraction (left ventricular ejection fraction 35.8±9.7

作者：Allison B, Hall；Maria C, Ziadi；Judith A, Leech；Shin-Yee, Chen；Ian G, Burwash；Jennifer, Renaud；Robert A, deKemp；Haissam, Haddad；Lisa M, Mielniczuk；Keiichiro, Yoshinaga；Ann, Guo；Li, Chen；Olga, Walter；Linda, Garrard；Jean N, DaSilva；John S, Floras；Rob S B, Beanlands

来源：Circulation 2014 年 130卷 11期