Microbleeds, small perivascular collections of hemosiderin manifested radiologically as hypointensities on gradient-echo magnetic resonance imaging (MRI), are important markers of small vessel pathology. Despite their clinical relevance, little is known about their prevalence and demographic correlates, particularly among ethnically diverse older adults. We examined demographic and clinical correlates of regional microbleeds in a multi-ethnic cohort and examined categorization schemes of microbleed distribution and severity.Between 2005 and 2007, 769 individuals participated in a MRI study as part of the Washington Heights/Inwood Columbia Aging Project. Approximately four years later, 243 out of 339 participants (mean age=84.50) who returned for a repeat MRI had gradient-echo scans for microbleed assessment and comprised the sample. We examined the association of deep and lobar microbleeds with age, sex, education, vascular factors, cognitive status and markers of small vessel disease.Sixty-seven of the 243 (27

作者：Anne F, Wiegman；Irene B, Meier；Nicole, Schupf；Jennifer J, Manly；Vanessa A, Guzman；Atul, Narkhede；Yaakov, Stern；Sergi, Martinez-Ramirez；Anand, Viswanathan；José A, Luchsinger；Steven M, Greenberg；Richard, Mayeux；Adam M, Brickman

来源：Journal of the neurological sciences 2014 年 345卷 1-2期