We set out to investigate whether MRI-visible centrum semiovale perivascular spaces (CSO-PVS), a potential biomarker of impaired interstitial fluid drainage in sporadic cerebral amyloid angiopathy, is associated with cortical superficial siderosis (cSS), reflecting recurrent hemorrhage from severe leptomeningeal and superficial cortical vascular amyloid.Retrospective multicenter cohort study of possible/probable cerebral amyloid angiopathy according to the Boston criteria. PVS were rated in basal ganglia and CSO (CSO-PVS) on axial T2-weighted sequences, using a validated 4-point visual rating scale and were classified as high (score>2) or low degree (score≤2) for prespecified analyses. Independent risk factors for high CSO-PVS degree were investigated in logistic regression.The final cohort consisted of 138 cerebral amyloid angiopathy patients (mean age, 71.8 years; 95

作者：Andreas, Charidimou；Rolf H, J?ger；Andre, Peeters；Yves, Vandermeeren；Patrice, Laloux；Jean-Claude, Baron；David J, Werring

来源：Stroke 2014 年 45卷 10期