Post-partum plasma C-peptide and ghrelin concentrations are predictive of type 2 diabetes in women with previous gestational diabetes mellitus.-临床诊疗知识库

Post-partum plasma C-peptide and ghrelin concentrations are predictive of type 2 diabetes in women with previous gestational diabetes mellitus.

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作者：

Martha, Lappas；Debra, Jinks；Antony, Ugoni；Connie C J, Louizos；Michael, Permezel；Harry M, Georgiou

来源：

Journal of diabetes 2015 年 7卷 4期

标签：

diabetes gestational diabetes mellitus metabolic hormones type 2 关键词：糖尿病，妊娠期糖尿病，2型代谢激素

Women with previous gestational diabetes mellitus (pGDM) are at increased risk of developing type 2 diabetes later in life. The aim of this study was to determine if circulating levels of metabolic hormones 12 weeks following a GDM pregnancy are associated with an increased risk of type 2 diabetes 8-10 years later.Fasting plasma concentrations of glucose, insulin, C-peptide, ghrelin, GIP, GLP-1, glucagon, leptin, PAI-1, resistin and visfatin were measured in 98 normal glucose tolerant women, 12 weeks following an index GDM pregnancy. Women were assessed every 2 years for up to 10 years for development of overt type 2 diabetes.After a median follow-up period of 8.7 years, 22.5

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