Iron oxide-containing magnetic nanoparticles (MNPs) have certain advantages over currently used contrast agents for tumor imaging by magnetic resonance imaging (MRI) as they offer the possibility of functionalization with ligands and tracers. Functionalized MNPs also may be used for targeted tumor therapy. In the current study nanoparticles (NPs) consisting of recombinant human serum albumin (rHSA) with incorporated hydrophilic (NH4)2Ce(IV)(NO3)6-γ-Fe2O3 particles (CAN maghemite particles) for medical imaging were produced and characterized. For this purpose CAN maghemite particles were incorporated into an rHSA matrix to yield rHSA-NPs. The resulting NPs were analyzed by transmission electron microscopy, photon correlation spectroscopy, and atomic absorption. The sizes of the manufactured NP were 170 ± 10 nm, and the zeta-potential was -50 ± 3 mV. The NPs remained stable when stored after lyophilization with sucrose 3

作者：Ina, Rosenberger；Christian, Schmithals；Jennifer, Vandooren；Silvia, Bianchessi；Paolo, Milani；Erica, Locatelli；Liron L, Israel；Frank, Hübner；Michela, Matteoli；Jean-Paul, Lellouche；Mauro Comes, Franchini；Lorena, Passoni；Eugenio, Scanziani；Ghislain, Opdenakker；Albrecht, Piiper；J?rg, Kreuter

来源：Journal of controlled release : official journal of the Controlled Release Society 2014 年 194卷