Higher angiotensin-converting enzyme (ACE) activity might increase the risk of Alzheimer's disease by increasing blood pressure, and subsequent development of cerebral small vessel disease (CSVD). Yet, it may also decrease this risk, as it functions to degrade amyloid-β, thereby reducing brain atrophy.To examine the cross-sectional associations of serum and cerebrospinal fluid (CSF) ACE protein levels and activity with brain atrophy and CSVD in a memory clinic cohort.In 118 subjects from the memory clinic based Amsterdam Dementia Cohort (mean age 66 ± 8 years), ACE protein levels (ng/ml) and activity in CSF and serum were investigated. Poisson regression analyses were used to associate ACE measurements with rated global cortical atrophy, medial temporal lobe atrophy, lacunar infarcts, white matter hyperintensities, and microbleeds on brain MRI.Higher CSF ACE activity was associated with a reduced risk of global brain atrophy. The relative risk (95

作者：Hadassa M, Jochemsen；Wiesje M, van der Flier；Emma L, Ashby；Charlotte E, Teunissen；Ruth E, Jones；Mike P, Wattjes；Philip, Scheltens；Mirjam I, Geerlings；Patrick G, Kehoe；Majon, Muller

来源：Journal of Alzheimer's disease : JAD 2015 年 44卷 1期