To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma.Prospective, longitudinal cohort study of cases and controls.We included 279 age-matched and follow-up time-matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma.Initial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area.α-Zone and β-zone PPA size over time.Intraclass correlation coefficients (ICCs) demonstrated that readers had good agreement on disc area (ICC = 0.97) and β-zone (ICC = 0.82), but not α-zone (ICC = 0.48). The ß-zone, as a percentage of disc area, increased in size (P < 0.001) in both eyes with incident primary open-angle glaucoma (mean, 10.6

作者：Eleonore, Savatovsky；Jean-Claude, Mwanza；Donald L, Budenz；William J, Feuer；Ruth, Vandenbroucke；Joyce C, Schiffman；Douglas R, Anderson

来源：Ophthalmology 2015 年 122卷 1期