Endometriosis is one of the most common gynecologic disorders. It is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. There is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. Glutathione-S-Transferase M1 (GSTM1) is one of the genes involved in detoxification of endogenous and exogenous compounds.Several studies have indicated an association between GSTM1 null mutation and endometriosis. In this study, the possible association between the GSTM1 gene null genotype and susceptibility to endometriosis in woman from central and southern Iran was investigated.One hundred and one unrelated premenopausal women with endometriosis and 142 unrelated healthy premenopausal women without endometriosis were enrolled in the study. Genomic DNA was extracted from Peripheral blood in all subjects. GSTM1 null genotyping was performed by polymerase chain reaction (PCR).There was no significant difference between frequencies of GSTM1 null genotype in case and control groups (50.5

作者：Seyed Morteza, Seifati；Kazem, Parivar；Abbas, Aflatoonian；Razieh, Dehghani Firouzabadi；Mohammad Hasan, Sheikhha

来源：Iranian journal of reproductive medicine 2012 年 10卷 1期