DJ-1 is a protein that is associated with Parkinson disease and cancer, and the reduction of DJ-1 function and expression is also thought to be a cause of diabetes and hypertension. However, little is known about the association between the plasma concentration of DJ-1 and risk of metabolic syndrome. We hypothesized that a lifestyle intervention would increase serum DJ-1 and that up-regulated DJ-1 functions will result in the prevention of metabolic syndrome. The objective of our study is to examine whether the level of serum DJ-1 is associated with the risk of metabolic syndrome. Therefore, to reveal the association between DJ-1 and metabolic syndrome, this study investigated lifestyle intervention in a control group (n = 37) and intervention group (n = 45). The results showed that body mass index, body fat ratio, waist-hip ratio, waist circumference, blood pressure, and plasma glucose level were improved in the intervention group, as compared with those in the control group. Furthermore, serum levels of DJ-1 were increased in the intervention group, when compared with those in the control group. These results suggest that serum DJ-1 is increased by lifestyle intervention and that increased serum DJ-1 prevents metabolic syndrome. Thus, the level of serum DJ-1 will become one of the indexes for the risk of metabolic syndrome.

作者：Takuya, Yamane；Sato, Murao；Miyuki, Kozuka；Mari, Shimizu；Junko, Suzuki；Chizuru, Kubo；Atsuko, Yamaguchi；Manabu, Musashi；Yukiko, Minegishi；Izumi, Momose；Mami, Matsushita；Aki, Shirahata；Naomi, Furukawa；Ryoko, Kobayashi；Atsuko, Umezawa；Megumi, Sakamoto；Kiyoshi, Moriya；Masayuki, Saito；Akira, Makita；Iwao, Ohkubo；Hiroyoshi, Ariga

来源：Nutrition research (New York, N.Y.) 2014 年 34卷 10期