Influenza is an acute respiratory illness caused by influenza A and B viruses. Complications may occur, especially among children and the elderly.To assess the effectiveness and safety of amantadine and rimantadine in preventing, treating and shortening the duration of influenza A in children and the elderly.We searched CENTRAL (2014, Issue 9), MEDLINE (1966 to September week 4, 2014) and EMBASE (1980 to October 2014).Randomised controlled trials (RCTs) or quasi-RCTs comparing amantadine and/or rimantadine with no intervention, placebo, other antivirals or different doses or schedules of amantadine or rimantadine in children and the elderly with influenza A.Two review authors independently assessed the search results. We extracted and analysed data using the standard Cochrane methodology.We identified 12 studies (2494 participants: 1586 children and 908 elderly) comparing amantadine and rimantadine with placebo, paracetamol (one trial: 69 children) or zanamivir (two trials: 545 elderly) to treat influenza A.Amantadine was effective in preventing influenza A in children (773 participants, risk ratio (RR) 0.11; 95

作者：Márcia G, Alves Galv?o；Marilene Augusta, Rocha Crispino Santos；Antonio J L, Alves da Cunha

来源：The Cochrane database of systematic reviews 2014 年 11期