Chlamydia trachomatis is a common sexually-transmitted bacterial pathogen. As no routine screening is performed during pregnancy, neonates and infants are at high risk for C. trachomatis infection. The objective of this study was to investigate the morbidity, clinical characteristics and genotype distribution of C. trachomatis pneumonia in infants less than six months of age.Clinical manifestations and laboratory results were recorded. Respiratory sputum specimens were tested using RT-PCR targeting C. trachomatis cryptic plasmid. Simultaneously, respiratory virus antigens were detected by direct immunofluorescence and bacterial pathogens were examined by culture in all sputum samples. Positive C. trachomatis samples were further genotyped using a multiplex PCR reverse line blot assay. The relationship between genotype and pneumonia severity was explored.Of 1408 infants, 101 (7.2
作者:Yuefeng, Li;Likuan, Xiong;Yan, Huang;Yong, Xia;Hua, Zhou;Fen, Xu;Matthew V N, O'Sullivan
来源:Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2015 年 29卷