The development of new therapeutic strategies is necessary to reduce the worldwide social and economic impact of cardiovascular disease, which produces high rates of morbidity and mortality. A therapeutic option that has emerged in the last decade is cell therapy. The aim of this study was to compare the effect of transplanting human umbilical cord-derived stromal cells (UCSCs), human umbilical cord blood-derived endothelial cells (UCBECs) or a combination of these two cell types for the treatment of ischemic cardiomyopathy (IC) in a Wistar rat model. IC was induced by left coronary artery ligation, and baseline echocardiography was performed seven days later. Animals with a left ventricular ejection fraction (LVEF) of ≤40

作者：Paula H, Suss；Luiz Guilherme A, Capriglione；Fabiane, Barchiki；Lye, Miyague；Danielle, Jackowski；Letícia, Fracaro；Andressa V, Schittini；Alexandra C, Senegaglia；Carmen L K, Rebelatto；Márcia, Olandoski；Alejandro, Correa；Paulo R S, Brofman

来源：Experimental biology and medicine (Maywood, N.J.) 2015 年 240卷 7期