Treatment with liraglutide in randomized controlled trials is associated with significant reductions in glycated hemoglobin (HbA1c) and weight loss in type 2 diabetes patients. The aim of this retrospective observational study was to investigate correlations of glycemic control and weight outcomes with baseline characteristics of patients starting liraglutide in outpatient clinics in Italy.Type 2 diabetes patients were followed from baseline to 4, 8, and 12 months. Changes in glycemic parameters, weight, blood pressure, and lipids were assessed. Subanalyses were performed according to baseline characteristics. Multivariate linear and logistic regressions were used to assess correlations between glycemic efficacy, weight reduction, and liraglutide discontinuation after 12 months and baseline characteristics.Four hundred and eighty-one patients were included. Mean (SD) age at baseline was 57.3 (9.2) years, diabetes duration was 9.5 (6.8) years, weight was 106.7 (20.8) kg, body mass index (BMI; calculated as kg/m(2)) was 37.1 (6.6), HbA1c was 8.7

作者：Annunziata, Lapolla；Vera, Frison；Michela, Bettio；Michela, Dal Pos；Paola, Rocchini；Giuseppe, Panebianco；Federica, Tadiotto；Virgilio, Da Tos；Michele, D'Ambrosio；Alberto, Marangoni；Maria, Ferrari；Alessandro, Pianta；Sara, Balzano；Loris, Confortin；Mario, Lamonica；Narciso, Marin；Marco, Strazzabosco；Elisabetta, Brun；Chiara Alberta, Mesturino；Maria, Simoncini；Francesco, Zen；Giuseppe, Bax；Barbara, Bonsembiante；Claudio, Cardone；Maria Grazia, Dal Frà；Alessandra, Gallo；Michela, Masin；Francesco, Piarulli；Giovanni, Sartore；Natalino, Simioni

来源：Clinical therapeutics 2015 年 37卷 3期