Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer.Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1.Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548 ± 0.333 ng/100 μL [n=51] for bladder cancer vs. 1.547 ± 0.319 ng/100 μL [n=55] for the control group), with a sensitivity and specificity of 93

作者：Ju Hyun, Shin；Sunga, Choi；Yu Ran, Lee；Myoung Soo, Park；Yong Gil, Na；Kaikobad, Irani；Sang Do, Lee；Jin Bong, Park；Jin Man, Kim；Jae Sung, Lim；Byeong Hwa, Jeon

来源：Cancer research and treatment : official journal of Korean Cancer Association 2015 年 47卷 4期