Culture, rapid urease test (RUT) and smear examination have been used as reliable methods for diagnosis of H. pylori infection. Accurate performance of these tests requires good quality biopsies with considerable number of bacterial cells. However, consumption of proton pump inhibitors (PPIs) affects growth and urease activity of H. pylori, leading to false negative results. In this study the efficacy of culture, RUT and smear examination was assessed and the effect of PPI consumption was evaluated.Two antral biopsies from 530 dyspeptic patients with and without PPI consumption were used for RUT, culture and smear examination. Statistical analysis was used to determine the association between results of culture, RUT or smear examination and PPI consumption. Sensitivity and specificity of three tests were calculated by standard methods.H. pylori infection was detected in 40

作者：Farideh, Siavoshi；Parastoo, Saniee；Saman, Khalili-Samani；Farideh, Hosseini；Fahimeh, Malakutikhah；Marzieh, Mamivand；Somayeh, Shahreza；Amir Houshang, Sharifi

来源：Annals of translational medicine 2015 年 3卷 1期