To evaluate the efficacy of dienogest + estradiol valerate (E2V) and gonadotrophin-releasing hormone analogue (GnRH-a) in reducing recurrence of pain in patients with chronic pelvic pain due to laparoscopically diagnosed and treated endometriosis.Multi-center, prospective, randomized study.Three university departments of obstetrics and gynecology in Italy.Seventy-eight women who underwent laparoscopic surgery for endometriosis combined with chronic pelvic pain.Post-operative administration of dienogest + E2V for 9 months (group 1) or GnRH-a monthly for 6 months (group 2).A visual analogue scale was used to test intensity of pain before laparoscopic surgery at 3, 6 and 9 months of follow up. A questionnaire to investigate quality of life was administered before surgery and at 9 months of follow up.The visual analogue scale score did not show any significant differences between the two groups (p = 0.417). The questionnaire showed an increase of scores for all women compared with pre-surgery values, demonstrating a marked improvement in quality of life and health-related satisfaction with both treatments. No significant differences were found between the groups. The rate of apparent endometriosis recurrence was 10.8

作者：Roberta, Granese；Antonino, Perino；Gloria, Calagna；Salvatore, Saitta；Pasquale, De Franciscis；Nicola, Colacurci；Onofrio, Triolo；Gaspare, Cucinella

来源：Acta obstetricia et gynecologica Scandinavica 2015 年 94卷 6期