Sterols, bile acids and their receptors have been involved in diabetic nephropathy. The ATP-binding cassette transporters G5 and G8 (ABCG5 and ABCG8) play an important role in intestinal sterol absorption and bile acid secretion. The aim of our study was to assess the associations between two ABCG8 coding polymorphisms, T400K and D19H, and the incidence of renal events in type 2 diabetic subjects.Participants were the 3137 French type 2 diabetic subjects with micro- or macro-albuminuria from the genetic substudy of the DIABHYCAR trial. The mean duration of follow-up was 4years. Renal events were defined as a doubling of serum creatinine concentration or end-stage renal disease at follow-up. We then used a second population (DIAB2NEPHROGENE) of 2140 type 2 diabetic patients for the purpose of validation.In DIABHYCAR, the 400K allele was significantly associated with a higher risk of incident renal events in a multiple adjusted model (HR: 1.75 [95

作者：Anthony, Nicolas；Sehrish, Fatima；Amel, Lamri；Naima, Bellili-Mu?oz；Jean-Michel, Halimi；Pierre-Jean, Saulnier；Samy, Hadjadj；Gilberto, Velho；Michel, Marre；Ronan, Roussel；Frédéric, Fumeron

来源：Metabolism: clinical and experimental 2015 年 64卷 6期