Fibromyalgia syndrome (FM) is a common disease characterized by generalized body pain, sensitivity in certain physical areas (sensitive points), lowered pain threshold, sleep disorder, and fatigue. The study aimed to determine the effects ACE I/D and MTHFR C677T gene polymorphisms in Turkish patients with FM and evaluate if there was an association with clinical features.This study included 200 FM patients and 190 healthy controls recruited from the department of Physical Medicine and Rehabilitation at Gaziosmanpasa University in Tokat, Turkey. ACE I/D polymorphism genotypes were determined by using polymerase chain reaction (PCR) by specific primers. The MTHFR C677T mutation was analyzed by PCR-based restriction fragment length polymorphism (RFLP) methods.We found a statistically significant relation between ACE polymorphism and FM (p<0.001, OR: 1.71, 95

作者：Ahmet, Inanir；Serbulent, Yigit；Akin, Tekcan；Ferda Alpaslan, Pinarli；Sema, Inanir；Nevin, Karakus

来源：Gene 2015 年 564卷 2期