8p deletion is strongly linked to poor prognosis in breast cancer.-临床诊疗知识库

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Deletions of chromosome 8p occur frequently in breast cancers, but analyses of its clinical relevance have been limited to small patient cohorts and provided controversial results. A tissue microarray with 2,197 breast cancers was thus analyzed by fluorescence in-situ hybridization using an 8p21 probe in combination with a centromere 8 reference probe. 8p deletions were found in 50

作者：P, Lebok；A, Mittenzwei；M, Kluth；C, ?zden；B, Taskin；K, Hussein；K, M?ller；A, Hartmann；A, Lebeau；I, Witzel；S, Mahner；L, W?lber；F, J?nicke；S, Geist；P, Paluchowski；C, Wilke；U, Heilenk?tter；R, Simon；G, Sauter；L, Terracciano；R, Krech；A, von der Assen；V, Müller；E, Burandt

来源：Cancer biology & therapy 2015 年 16卷 7期

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8p deletion is strongly linked to poor prognosis in breast cancer.

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作者：

P, Lebok；A, Mittenzwei；M, Kluth；C, ?zden；B, Taskin；K, Hussein；K, M?ller；A, Hartmann；A, Lebeau；I, Witzel；S, Mahner；L, W?lber；F, J?nicke；S, Geist；P, Paluchowski；C, Wilke；U, Heilenk?tter；R, Simon；G, Sauter；L, Terracciano；R, Krech；A, von der Assen；V, Müller；E, Burandt

来源：

Cancer biology & therapy 2015 年 16卷 7期

标签：

8p ER, estrogen receptor FISH FISH, fluorescence in situ hybridization HER2, human epidermal growth factor receptor 2 Ki67LI, Ki67 Labeling index LOH, loss of heterozygosity NGS, next generation sequencing NST, no special type PR, progesterone receptor TMA, tissue microarray breast cancer deletion pN, nodal stage pT, pathological tumor stage prognosis

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