The case-crossover (CXO) and self-controlled case series (SCCS) designs are increasingly used in pharmacoepidemiology. In both, relative risk estimates are obtained within persons, implicitly controlling for time-fixed confounding variables.To examine the consistency of relative risk estimates of hip/femur fractures (HFF) associated with the use of benzodiazepines (BZD) across case-only designs in two databases (DBs), when a common protocol was applied.CXO and SCCS studies were conducted in BIFAP (Spain) and CPRD (UK). Exposure to BZD was divided into non-use, current, recent and past use. For CXO, odds ratios (OR; 95

作者：Gema, Requena；John, Logie；Elisa, Martin；Nada, Boudiaf；Rocío, González González；Consuelo, Huerta；Arturo, Alvarez；David, Webb；Andrew, Bate；Luis A, García Rodríguez；Robert, Reynolds；Raymond, Schlienger；Helga, Gardarsdottir；Mark, de Groot；Olaf H, Klungel；Fancisco, de Abajo；Ian J, Douglas

来源：Pharmacoepidemiology and drug safety 2016 年 25 Suppl 1卷