Adaptive radiotherapy (ART) can account for the dosimetric impact of anatomical change in head and neck cancer patients; however it can be resource intensive. Consequently, it is imperative that patients likely to require ART are identified. The purpose of this study was to find predictive factors that identify oropharyngeal squamous cell carcinoma (OPC) and nasopharyngeal carcinoma (NPC) patients more likely to need ART.One hundred and ten patients with OPC or NPC were analysed. Patient demographics and tumour characteristics were compared between patients who were replanned and those that were not. Factors found to be significant were included in logistic regression models. Risk profiles were developed from these models. A dosimetric analysis was performed.Nodal disease stage, pre-treatment largest involved node size, diagnosis and initial weight (categorised in 2 groups) were identified as significant for inclusion in the model. Two models were found to be significant (p=0.001), correctly classifying 98.2

作者：Elizabeth, Brown；Rebecca, Owen；Fiona, Harden；Kerrie, Mengersen；Kimberley, Oestreich；Whitney, Houghton；Michael, Poulsen；Selina, Harris；Charles, Lin；Sandro, Porceddu

来源：Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2015 年 116卷 1期