Placenta-mediated complications are leading causes of maternal and fetal morbidity and mortality. We hypothesized that a preconception history of venous thromboembolism (VTE) is associated with increased risk of placenta-mediated pregnancy complications.A nationwide population-based cohort study of all singleton pregnancies leading to delivery from 1997 to 2012 (n = 964 967). We obtained data on placenta-mediated pregnancy complications from the Danish Medical Birth Registry and data on VTE before pregnancy from the Danish National Patient Registry. We computed absolute risks, crude and adjusted risk differences (RDs) using a binomial regression model, and crude and adjusted risk ratios (RRs) from a modified Poisson regression model.Overall, 1419 women had a preconception history of VTE, while 578 112 did not. Preeclampsia occurred in 4.2

作者：A T, Hansen；M, Schmidt；E, Horváth-Puhó；L, Pedersen；K J, Rothman；A M, Hvas；H T, S?rensen

来源：Journal of thrombosis and haemostasis : JTH 2015 年 13卷 9期