Topical glucocorticosteroids were incorporated into nanocarrier-based formulations, to overcome side effects of conventional formulations and to achieve maximum skin deposition. Nanoparticulate carriers have the potential to prolong the anti-inflammatory effect and provide higher local concentration of drugs, offering a better solution for treating dermatological conditions and improving patient compliance. Nanoparticles were formulated with poly-ϵ-caprolactone as the polymeric core along with stearic acid as the fatty acid, for incorporation of betamethasone-21-acetate. Oleic acid was applied as the coating fatty acid. Improvement of the drug efficacy, and reduction in drug degradation with time in the encapsulated form was examined, while administering it locally through controlled release. Nanoparticles were spherical with mean size of 300 nm and negatively charged surface. Encapsulation efficiency was 90

作者：Catarina Oliveira, Silva；Patrícia, Rijo；Jesús, Molpeceres；Isabel Vitória, Figueiredo；Lia, Ascens?o；Ana Sofia, Fernandes；Amílcar, Roberto；Catarina Pinto, Reis

来源：International journal of pharmaceutics 2015 年 493卷 1-2期