AMPK is considered to have a role in regulating skeletal muscle mass. However, there are no studies investigating the function of AMPK in modulating skeletal muscle mass during atrophic conditions. In the present study, we investigated the difference in unloading-associated muscle atrophy and molecular functions in response to 2-wk hindlimb suspension between transgenic mice overexpressing the dominant-negative mutant of AMPK (AMPK-DN) and their wild-type (WT) littermates. Male WT (n = 24) and AMPK-DN (n = 24) mice were randomly divided into two groups: an untreated preexperimental control group (n = 12 in each group) and an unloading (n = 12 in each group) group. The relative soleus muscle weight and fiber cross-sectional area to body weight were decreased by ∼30

作者：Tatsuro, Egawa；Ayumi, Goto；Yoshitaka, Ohno；Shingo, Yokoyama；Akihiro, Ikuta；Miho, Suzuki；Takao, Sugiura；Yoshinobu, Ohira；Toshitada, Yoshioka；Tatsuya, Hayashi；Katsumasa, Goto

来源：American journal of physiology. Endocrinology and metabolism 2015 年 309卷 7期