DIS3 is a catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) domains, recently found mutated in multiple myeloma (MM), a clinically and genetically heterogeneous form of plasma cell (PC) dyscrasia. We analyzed by next-generation sequencing (NGS) the DIS3 PIN and RNB domains in purified bone marrow PCs from 164 representative patients, including 130 cases with MM, 24 with primary PC leukemia and 10 with secondary PC leukemia. DIS3 mutations were found respectively in 18.5
作者:Marta, Lionetti;Marzia, Barbieri;Katia, Todoerti;Luca, Agnelli;Sonia, Fabris;Giovanni, Tonon;Simona, Segalla;Ingrid, Cifola;Eva, Pinatel;Pierfrancesco, Tassone;Pellegrino, Musto;Luca, Baldini;Antonino, Neri
来源:Oncotarget 2015 年 6卷 28期