Antibody mediated rejection (AMR) can significantly influence the results of orthotopic heart transplantation (OHT). However, AMR and cellular rejection (CR) coexistence is poorly described. Therefore we performed a prospective pilot study to assess AMR/CR concomitance in endomyocardial biopsies (EMBs) obtained electively in 27 OHT recipients (21 M/6 F, 45.4 ± 14.4 y/o). Biopsy samples were paraffin embedded and processed typically with hematoxylin/eosin staining to assess CR, and, if a sufficient amount of material remained, treated with immunohistochemical methods to localize particles C3d and C4d as markers of antibody dependent complement activation. With this approach 80 EMBs, including 41 (51

作者：Micha?, Zakliczyński；Jerzy, No?yński；Dominika, Konecka-Mrówka；Agnieszka, Babińska；Bo?ena, Flak；Tomasz, Hrapkowicz；Marian, Zembala

来源：Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery 2014 年 11卷 1期