The celiac iceberg: from the clinical spectrum to serology and histopathology in children and adolescents with type 1 diabetes mellitus and Down syndrome.-临床诊疗知识库

The celiac iceberg: from the clinical spectrum to serology and histopathology in children and adolescents with type 1 diabetes mellitus and Down syndrome.

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作者：

Rosane, Costa Gomes；Jussara, Cerqueira Maia；Ricardo, Fernando Arrais；Carlos, André Nunes Jatobá；Maria, Auxiliadora Carvalho Rocha；Maria, Edinilma Felinto Brito；Ana, Laissa Oliveira Nazion；Clarissa, Marques Maranh?o；Hélcio, De Sousa Maranh?o

来源：

Scandinavian journal of gastroenterology 2016 年 51卷 2期

标签：

Coeliac-disease Down syndrome celiac iceberg children serological markers type1 diabetes mellitus

The objective of this study is to investigate the occurrence of gastrointestinal (GI) and extraintestinal symptoms in children and adolescents with type 1 diabetes mellitus (DM1) and Down syndrome (DS) and their association with specific antibodies and histopathology of celiac disease (CelD), representing its clinical forms in the iceberg.Cross-sectional study (November 2009-December 2012) conducted at an outpatient care facility in Northeast Brazil including patients [DM1 (n = 111); DS (n = 77)] aged 10 months-18 years old. Measurement of anti-endomysial (EmA) and anti-tissue transglutaminase (anti-tTG) IgA antibodies was performed, as was that of anti-tTG-IgG in the cases with low serum IgA. The patients with antibody positivity were subjected to small intestine biopsy.GI symptoms occurred in 53.7

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