Telmisartan (TEL) was entrapped into β-cyclodextrin aiming the improvement of its biopharmaceutical properties of low solubility. A solid state grinding process was used to prepare the molecular inclusion complex (MIC) for up to 30min. The inclusion ratio of drug and β-cyclodextrin was established as 1:2 and 1:3 (mol/mol) by phase solubility study and Job Plot. DSC, XRPD and FTIR confirmed the molecular interactions between TEL and β-cyclodextrin. Computer molecular modeling supports the presence of hydrogen bonds between guest and host and demonstrated the most probable complexes configuration. MIC_1:2_30 and MIC_1:3_30 enhanced the dissolution rate of the drug achieving a delivery rate comparable with the reference medicine available in the market (81

作者：Paola Aline Amarante, Borba；Marihá, Pinotti；George Ricardo Santana, Andrade；Nivan Bezerra, da Costa；Luiz Renato, Olchanheski Junior；Daniel, Fernandes；Carlos Eduardo Maduro, de Campos；Hellen Karine, Stulzer

来源：Carbohydrate polymers 2015 年 133卷