Patients with stage IIIB-IV lung adenocarcinoma are at high-risk for pulmonary embolism (PE). In these patients, EGFR and KRAS mutations as well as EML4/ALK rearrangements are recognized as "drivers" and as targets for therapy. Data on the incidence of PE in oncogene-addicted lung cancer patients are limited.The aims of this study were to evaluate the incidence of CT scan-detected PE in patients with stage IIIB-IV lung adenocarcinoma and to assess the potential correlation between the presence of these oncogenes and the PE risk.Baseline staging or re-staging chest contrast-enhanced CT scans of patients with stage IIIB-IV lung adenocarcinoma were retrospectively reviewed and adjudicated for the presence of PE. Data on the oncogene drivers (EGFR, KRAS or EML4/ALK) of the same patients were collected.A total of 173 patients with lung adenocarcinoma were included in the study. 24.8

作者：Melina, Verso；Rita, Chiari；Stefano, Mosca；Laura, Franco；Matthias, Fischer；Luca, Paglialunga；Chiara, Bennati；Michele, Scialpi；Giancarlo, Agnelli

来源：Thrombosis research 2015 年 136卷 5期