To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.

作者：Stefano, Lazzeri；Paola, Orlandi；Paolo, Piaggi；Maria Sole, Sartini；Giamberto, Casini；Gianluca, Guidi；Michele, Figus；Anna, Fioravanti；Teresa, Di Desidero；Guido, Ripandelli；Mariacristina, Parravano；Monica, Varano；Marco, Nardi；Guido, Bocci

来源：Pharmacogenomics 2016 年 17卷 1期