The subventricular zone (SVZ) and the corpus callosum (CC) invasion status are separately associated with adverse prognosis for glioblastoma. We investigated the prognosis and progression patterns of glioblastoma with and without synchronous SVZ and CC (sSVZCC) invasion.Glioblastoma patients completing concurrent chemoradiotherapy with temozolomide were retrospectively categorized by the preoperative sSVZCC invasion status. The associations between sSVZCC invasion and the survival and progression patterns were analyzed.In total, 108 patients, including 36 with sSVZCC invasion, were followed for a median period of 60.2 (range 34.2-86.3) months. The median overall survival (OS) of patients with and without sSVZCC were 18.6 and 26.4 months, respectively (p=0.005). Using multivariate analyses with the factors of age, performance, surgery extent, and tumor size, sSVZCC invasion remained significant for a poor OS (hazard ratio, 1.96; 95
作者:Tony Hsiang-Kuang, Liang;Sung-Hsin, Kuo;Chun-Wei, Wang;Wan-Yu, Chen;Che-Yu, Hsu;Shih-Fan, Lai;Ham-Min, Tseng;San-Lin, You;Chung-Ming, Chen;Wen-Yih Isaac, Tseng
来源:Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2016 年 118卷 1期