Children with type 1 diabetes mellitus (T1DM) are at increased risk of coeliac disease (CD). Recent guidelines indicate coeliac screening should include HLA typing for CD predisposing (DQ2/DQ8) alleles and those negative for these alleles require no further coeliac screening.Children (n=176) with T1DM attending clinics across two Scottish regions were screened for HLA DQ2/DQ8 as part of routine screening. Data collected included the frequency of DQ2/DQ8 genotypes and the additional cost of HLA screening.Overall, DQ2/DQ8 alleles were identified in 94
作者：R T, Mitchell；A, Sun；A, Mayo；M, Forgan；A, Comrie；P M, Gillett
来源：Archives of disease in childhood 2016 年 101卷 3期
