Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors.-临床诊疗知识库

Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors.

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作者：

Steven E, Lipshultz；Lynn M, Anderson；Tracie L, Miller；Mariana, Gerschenson；Kristen E, Stevenson；Donna S, Neuberg；Vivian I, Franco；Daniel E, LiButti；Lewis B, Silverman；Lynda M, Vrooman；Stephen E, Sallan

来源：

Cancer 2016 年 122卷 6期

标签：

childhood cancer survivors dexrazoxane doxorubicin mitochondrial DNA mitochondrial function

Impaired cardiac function in doxorubicin-treated childhood cancer survivors is partly mediated by the disruption of mitochondrial energy production. Doxorubicin intercalates into mitochondrial DNA (mtDNA) and disrupts genes encoding for polypeptides that make adenosine triphosphate.This cross-sectional study examined mtDNA copy numbers per cell and oxidative phosphorylation (OXPHOS) in peripheral blood mononuclear cells (PBMCs) in 64 childhood survivors of high-risk acute lymphoblastic leukemia (ALL) who had been treated on Dana-Farber Cancer Institute childhood ALL protocols and had received doxorubicin alone (42

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