Elevated serum leptin levels following rapid therapeutically induced weight gain in anorexia nervosa (AN) patients are discussed as a potential biomarker for renewed weight loss as a result of leptin-related suppression of appetite and increased energy expenditure. This study aims to analyze the predictive value of leptin levels at discharge as well as the average rate of weight gain during inpatient or day patient treatment for body weight at 1-year follow-up. 121 patients were recruited from the longitudinal Anorexia Nervosa Day patient versus Inpatient (ANDI) trial. Serum leptin levels were analyzed at referral and discharge. A multiple linear regression analysis to predict age-adjusted body mass index (BMI-SDS) at 1-year follow-up was performed. Leptin levels, the average rate of weight gain, premorbid BMI-SDS, BMI-SDS at referral, age and illness duration were included as independent variables. Neither leptin levels at discharge nor rate of weight gain significantly predicted BMI-SDS at 1-year follow-up explaining only 1.8 and 0.4
作者:Jochen, Seitz;Katharina, Bühren;Ronald, Biemann;Nina, Timmesfeld;Astrid, Dempfle;Sibylle Maria, Winter;Karin, Egberts;Christian, Fleischhaker;Christoph, Wewetzer;Beate, Herpertz-Dahlmann;Johannes, Hebebrand;Manuel, F?cker
来源:European child & adolescent psychiatry 2016 年 25卷 9期