To demonstrate a method for correlating photoreceptor mosaic structure with optical coherence tomography (OCT) and microperimetry findings in patients with Stargardt disease.A total of 14 patients with clinically diagnosed Stargardt disease were imaged using confocal and split-detection adaptive optics scanning light ophthalmoscopy. Cone photoreceptors were identified manually in a band along the temporal meridian. Resulting values were compared to a normative database (n = 9) to generate cone density deviation (CDD) maps. Manual measurement of outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness was performed, in addition to determination of the presence of ellipsoid zone (EZ) and interdigitation zone (IZ) bands on OCT. These results, along with microperimetry data, were overlaid with the CDD maps.Wide variation in foveal structure and CDD maps was seen within this small group. Disruption of ONL+HFL and/or IZ band was seen in all patients, with EZ band preservation in regions with low cone density in 38

作者：Moataz M, Razeen；Robert F, Cooper；Christopher S, Langlo；Mara R, Goldberg；Melissa A, Wilk；Dennis P, Han；Thomas B, Connor；Gerald A, Fishman；Frederick T, Collison；Yusufu N, Sulai；Alfredo, Dubra；Joseph, Carroll；Kimberly E, Stepien

来源：Translational vision science & technology 2016 年 5卷 2期