It is hypothesized that impaired kidney function and cerebral microbleeds represent microvascular damage in different organs. Several cross-sectional studies found impaired kidney function to be associated with the presence of cerebral microbleeds.To further confirm the association between both small vessel diseases, we aimed to determine whether kidney function is related to progression of cerebral microbleeds in a longitudinal study design.In 89 lacunar stroke patients, baseline brain magnetic resonance imaging (including gradient-echo images), baseline estimated glomerular filtration rate (eGFR), blood pressure measurements, and follow-up brain magnetic resonance imaging after two years were available. Presence of cerebral microbleeds on baseline and follow-up magnetic resonance imaging was scored visually. Cerebral microbleeds progression was defined as the presence of any new microbleed on follow-up magnetic resonance imaging. The association between cerebral microbleeds progression (dependent variable) and eGFR (independent variable) was assessed by logistic regression analysis.Cerebral microbleeds progression was present in 17 patients (19.1

作者：Ellen C, van Overbeek；Julie, Staals；Robert J, van Oostenbrugge

来源：International journal of stroke : official journal of the International Stroke Society 2016 年 11卷 6期