Alcohol consumption is a potentially modifiable risk factor for dementia, but the literature is not completely consistent. This inconsistency may be partly due to an interaction with the apolipoprotein E (APOE) genotype, an established risk factor for Alzheimer's dementia. The aim of this study was to examine whether alcohol consumption is associated with incident dementia or decline in specific cognitive domains over 4 years, and if this effect is modified by APOEɛ4 status. Non-demented community dwelling older adults (70-90 years) from an ongoing longitudinal study were assessed for cognitive impairment in attention/processing speed, language, executive function, visuospatial ability, and memory. Incident dementia was diagnosed according to DSM-IV criteria. Compared to those who did not drink in the previous 12 months, neither low consumption (HR 0.64 95

作者：Megan, Heffernan；Karen A, Mather；Jing, Xu；Amelia A, Assareh；Nicole A, Kochan；Simone, Reppermund；Brian, Draper；Julian N, Trollor；Perminder, Sachdev；Henry, Brodaty

来源：Journal of Alzheimer's disease : JAD 2016 年 52卷 2期