Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system requiring long-term treatment, which is often hampered by non-adherence to self-applicable therapies, provoking continued disease activity and health care system burdens. This study assessed the influence of a personal digital assistant (PDA) with diary function (n = 339 patients) on persistence and adherence to an interferon beta treatment regimen in comparison to a paper patient diary (n = 330 patients).Patients who recently started with subcutaneous injections of interferon beta-1b were recruited in this prospective, non-interventional, national cohort study for an observational period of 2 years after successful completion of the initial dose escalation.Therapy persistence as assessed by the drop-out rate within 104 weeks was about 50

作者：Uwe Klaus, Zettl；Ulrike, Bauer-Steinhusen；Thomas, Glaser；J?rg, Czekalla；Klaus, Hechenbichler；Volker, Limmroth；Michael, Hecker

来源：Advances in therapy 2016 年 33卷 5期