Does DNAH1 status influence intracytoplasmic sperm injection (ICSI) outcomes for patients with multiple morphological abnormalities of the sperm flagella (MMAF)?Despite a highly abnormal morphology, sperm from MMAF patients with DNAH1 mutations have a low aneuploidy rate and good nuclear quality, leading to good embryonic development following ICSI and a high pregnancy rate.Teratozoospermia represents a heterogeneous group including a wide range of phenotypes. Among all these qualitative defects, a flagellar phenotype called MMAF is characterized by a mosaic of morphological abnormalities of the flagellum, including coiled, bent, irregular, short or/and absent flagella, mainly due to the absence of the axonemal central pair microtubules. We previously demonstrated that homozygous mutations in the DNAH1 gene, encoding an inner arm heavy chain dynein, are frequently found in patients with MMAF (28

作者：Clémentine, Wambergue；Raoudha, Zouari；Selima, Fourati Ben Mustapha；Guillaume, Martinez；Fran?oise, Devillard；Sylviane, Hennebicq；Véronique, Satre；Sophie, Brouillet；Lazhar, Halouani；Ouafi, Marrakchi；Mounir, Makni；Habib, Latrous；Mahmoud, Kharouf；Florence, Amblard；Christophe, Arnoult；Pierre F, Ray；Charles, Coutton

来源：Human reproduction (Oxford, England) 2016 年 31卷 6期