The relation of knee replacement (KR) surgery to all-cause mortality has not been well established owing to potential biases in previous studies. Thus, we aimed to examine the relation of KR to mortality risk among patients with knee osteoarthritis (OA) focusing on identifying biases that may threaten the validity of prior studies.We included knee OA subjects (ages 50-89 years) from The Health Improvement Network, an electronic medical records database in the UK. Risk of mortality among KR subjects was compared with propensity score-matched non-KR subjects. To explore residual confounding bias, subgroup analyses stratified by age and propensity scores were performed.Subjects with KR had 28

作者：Devyani, Misra；Na, Lu；David, Felson；Hyon K, Choi；John, Seeger；Thomas, Einhorn；Tuhina, Neogi；Yuqing, Zhang

来源：Annals of the rheumatic diseases 2017 年 76卷 1期