Whether the impact of backward wave pressures (Pbs) on left ventricular (LV) diastolic dysfunction (DD) antedates the effects of aortic stiffness is uncertain. We compared the relative contribution of various aortic hemodynamic parameters to preclinical DD in a predominantly young-to-middle-aged community-based sample.In 524 randomly selected participants of African ancestry (mean age = 46.8±18.4 years), we assessed central aortic pulse pressure (PPc), forward wave pressure (Pf), Pb, augmented pressure (Pa), the time-to-wave reflection (Rt), and aortic pulse wave velocity (PWV) using applanation tonometry (SphygmoCor software). LV mass index (LVMI), early to late transmitral velocity (E/A), and E/velocity of myocardial tissue lengthening (E/e') were determined using echocardiography.Independent of age, sex, mean arterial pressure, body mass index, diabetes mellitus and/or HbA1c > 6.1

作者：Vernice R, Peterson；Angela J, Woodiwiss；Carlos D, Libhaber；Andrew, Raymond；Pinhas, Sareli；Gavin R, Norton

来源：American journal of hypertension 2016 年 29卷 10期