Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.-临床诊疗知识库

Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.

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作者：

Lei, Quan；Koushik, Chattopadhyay；Heather H, Nelson；Kenneth K, Chan；Yong-Bing, Xiang；Wei, Zhang；Renwei, Wang；Yu-Tang, Gao；Jian-Min, Yuan

来源：

Oncotarget 2016 年 7卷 26期

标签：

N-acetylation NAT2 O-acetylation bladder cancer case-control

N-acetyltransferase 2 (NAT2) is involved in both carcinogen detoxification through hepatic N-acetylation and carcinogen activation through local O-acetylation. NAT2 slow acetylation status is significantly associated with increased bladder cancer risk among European populations, but its association in Asian populations is inconclusive.NAT2 acetylation status was determined by both single nucleotide polymorphisms (SNPs) and caffeine metabolic ratio (CMR), in a population-based study of 494 bladder cancer patients and 507 control subjects in Shanghai, China.The CMR, a functional measure of hepatic N-acetylation, was significantly reduced in a dose-dependent manner among both cases and controls possessing the SNP-inferred NAT2 slow acetylation status (all P-values<5.0×10-10). The CMR-determined slow N-acetylation status (CMR<0.34) was significantly associated with a 50

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