Homocitrulline as marker of protein carbamylation in hemodialyzed patients.-临床诊疗知识库

Homocitrulline as marker of protein carbamylation in hemodialyzed patients.

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作者：

Stéphane, Jaisson；Isabelle, Kazes；Aurore, Desmons；Fouad, Fadel；Jean-Baptiste, Oudart；Izabella C R Dos, Santos-Weiss；Hervé, Millart；Fatouma, Touré；Philippe, Rieu；Philippe, Gillery

来源：

Clinica chimica acta; international journal of clinical chemistry 2016 年 460卷

标签：

Biomarker Carbamylation End-stage renal disease Hemodialysis Homocitrulline

Homocitrulline (HCit) is a carbamylation-derived product (CDP) that has been identified as a valuable biomarker of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of this study was to determine whether initiation of hemodialysis therapy (HD) could induce variations of HCit concentrations in CKD patients.Serum HCit concentrations were determined by LC-MS/MS in CKD patients (n=108) just before (M0) and six months (M6) after the initiation of HD therapy.Mean HCit concentrations reached 1000μmol/mol Lysine before initiation of HD therapy and decreased by 50

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